Sema7A interaction with α1β1 integrin is critical for axonal growth (Parkash et al., 2015; Pasterkamp et al., 2003), whereas epithelial Sema7A binding to macrophage αvβ5 integrin is crucial for anti-inflammatory IL-10 secretion in a colitis model (Kang et al., 2012). This evidence concerns the gene SEMA7A and colitis.