In addition, miR-296-3p can reduce the resistance of αTC1–6 cells to apoptosis induced by cytokines, such as IFN-γ, IL-1β and TNF-α, suggesting its involvement in the regulation of Type 2 diabetes (Barbagallo et al. 2013; Dunning and Gerich 2007). This evidence concerns the gene TNF and type 2 diabetes mellitus.