The common denominator of most of the altered mitochondrial mechanisms is the peroxisome proliferator activated receptor gamma, coactivator 1 alpha (PGC-1α or PPARGC1A) - a key modulator of mitochondrial function (Scarpulla et al. 2012) – which is significantly downregulated in DS samples (Piccoli et al. 2013) (Conti et al. 2007). The gene discussed is PPARGC1A; the disease is Dravet syndrome.