MALAT1 is upregulated in tumour tissues from mantle cell lymphoma (MCL) patients compared to normal B-cells, and knockdown of MALAT1 results in cell cycle arrest due to upregulation of p21 and p27 through enhancer of zeste homolog 2 (EZH2), a component of the polycomb repressive complex 2 (PRC2) [63]. Here, EZH2 is linked to mantle cell lymphoma.