As reported by Miao et al. BMSCs offer some advantages for therapeutic treatment of cardiac disease, as they may support cardiac regeneration through paracrine effect, secreting several growth factors, such as cytokines like vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), interleukin (IL)-6, platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF) [27]. This evidence concerns the gene VEGFA and heart disorder.