Following a preliminary study on early-stage NSCLC comprising both adenocarcinomas and pSQCC [21] we investigated the relevance of LC3B, p62/SQSTM1 (short p62), and HMGB1 expression in a well-characterized cohort of pSQCCs [22] as a potential rationale for autophagy directed therapy in pSQCC. Here, SQSTM1 is linked to adenocarcinoma.