CD4 and neoplasm: In a previous study by Pakish et al. [32], MSI-high cases were associated with higher Granzyme B+ cells (representing activated cytotoxic T lymphocyte (CTL), or natural killer cells), PD-L1+ cells, CD3+ cells, CD4+ cells, and CD8+ Granzyme B+ cells (activated CTL) in the tumor stroma, compared with MSS cases; PLS cases were associated with higher CD8+ cells (CTL), CD8+ Granzyme B+ cells (activated CTL), and PD-L1+ CD68+ cells (PD-L1+ macrophages).