SMO and cancer: However, based on recent work indicating that anti-cancer therapy using selective BRAF inhibitors may activate FAK pathway [122,123], GSK2256098 was also tested in combination with the MEK inhibitor trametinib in a Phase Ib study in subjects with advanced solid tumours and in combination with the frizzled class receptor (SMO) inhibitor vismodegib in a phase II study in patients with progressive meningiomas harbouring mutations in SMO or NF2.