TP53 and cancer: Several small compounds were selected and notably the compound 1-benzyl-15,3,5,7-tetraazatricyclo [3.3.1.1~3,7~] decane, named Roslin2 were able to reactivate p53 in colon cancer cells both in vitro and in-vivo and to sensitize cancer cells to doxorubicin and 5-fluorouracil.