At the earliest time of infection, i.e. envelope fusion, the HCMV glycoproteins B and H (gB/gH), encoded by UL55 and UL75, respectively, bind to Toll-like receptor 2 (TLR-2) on the surface of the cell and induce a canonical NFκB signaling cascade resulting in the excretion of pro-inflammatory and anti-viral cytokines [92]. The gene discussed is NFKB1; the disease is infection.