MSLN and ovarian carcinoma: The MSLN:CA125 role in cell attachment is supported by work from Bruney et al., demonstrating the overexpression of membrane type 1 matrix metalloproteinase (MT1-MMP) in human ovarian cancer cells (OVCA433-MT)-decreased cell surface expression of CA125/MUC16, subsequently increasing CA125/MUC16 ectodomain shedding, resulting in the release of CA125 from the cell surface.