We found increasedexpression of MFGE8 in the frontal cortex of FTD cases with MAPT mutations (P301L and FTDP+3) or sporadicPick’s disease but not in the cerebellum of P301L cases, showing that the expression level of MFGE8 depends on the presence oftau aggregates. This evidence concerns the gene MFGE8 and frontotemporal dementia.