Microglial activation has been associated with tau aggregation in frontotemporal dementia (FTDP-17T) (Bellucci et al., 2011) and P301S-tau mouse brains (Bellucci et al.,2004) and has also been implicated in tau spreading through phagocytosis (Bolos et al.,2016; Ma- phis et al., 2015). The gene discussed is MAPT; the disease is frontotemporal dementia.