To determine whether a similar pattern of activation occurs in human tauopathies, we compared the expression of MFGE8 inbrain extracts from the frontal cortex of healthy human controls and three cases each of inherited tauopathies (P301L and +3mutations in MAPT; Hutton et al., 1998; Mirra et al., 1999; Spill- antini et al., 1997) and three cases of sporadicPick’s disease (case details in STAR Methods). Here, MAPT is linked to tauopathy.