CCL2 and inflammation: Neutrophil infiltration induced by MIP‐2 and MCP‐1 plays an important role in liver inflammation and is also a major cause of liver damage.34, 35, 36 As well, LPS or LPS/GalN induces ICAM‐1 and VCAM‐1 expression in liver cells, which facilitates neutrophil infiltration.10, 11, 37 Deletion of Cav‐1 sequesters neutrophil adhesion to endothelial cells by suppressing NF‐κB activation and ICAM‐1 expression in LPS‐induced lung injury in mice.16 Accordingly, suppressed neutrophil infiltration in Cav‐1−/− mouse livers was associated with suppressed MIP‐2, MCP‐1, ICAM‐1 and VCAM‐1 expression.