ALOX15 and malignant colon neoplasm: Regarding the roles of 15-LOX-1 and 15-LOX-2 in cancer, one of the first studies to propose an antitumorigenic role for 15-LOX-1 showed a decrease in 13-HODE production and 15-LOX-1 expression in 18 colon cancer samples compared with those in normal colon samples 140.