The association between BDNF levels and predictors of poor prognosis in ChC has also been reported in another study13, which found a positive correlation between serum BDNF and LVEF levels (r = 0.3137, p = 0.0431) and a negative correlation with ventricular dilatation index (r = -0.3146, p = 0.0424). This evidence concerns the gene BDNF and cryohydrocytosis.