CD4+ T cells isolated from the lungs of Nlrc3-/- mice showed stronger expression of intracellular IFN-γ, TNF-α and IL-17A after restimulation than that showed by CD4+ T cells isolated from lungs of WT mice (Fig 1A, S1A Fig) at 3 weeks post-infection (w.p.i.). This evidence concerns the gene CD4 and infection.