The present study showed that the effects of resistance training and caloric restriction, performed separately or combined, were efficient interventions to prevent OVX-induced endothelial dysfunction by altering and ameliorating endothelial function, elevating MMP-2 activity, preventing insulin resistance, decreasing collagen deposition and promoting beneficial aortic wall remodeling, which together maintain the normal values of SBP in OVX rats. Here, MMP2 is linked to endothelial dysfunction.