CHMP5 and infection: However, CHMP5 has low activity at the first infection stage because it is degraded following ubiquitination by the ubiquitin ligase protein HUWE1, which reduces the expression of CHMP5 so that the low activity of TFs (GATA2 and AR) causes a decrease in the transcriptional silencing of human genes TGFB1I1 and PTK7, which are thereby highly expressed (p-value = 5.37 × 10−3 and p-value = 2.96 × 10−13, respectively).