Compared to non-aspirin users, there were more patients who were older (52.9 versus 49.5 years old), inhabited in the non-urban area, and having comorbidity including CHD, hypertension, DM, Af, HF, hyperlipidemia and CKD, and taking medicines of COX2 inhibitor and statins. The gene discussed is PTGS2; the disease is hypertensive disorder.