TLR2 and early-onset autosomal dominant Alzheimer disease: SNP rs7656500 (uLR β^G=0.79,p=0.01 and pMLE-DX β^G=6,p=0.02) locates at the intergenic region between KIAA0922 and TLR2 at Chromosome 4, and is 163k upstream and 144k downstream of rs727153 and rs1466662, respectively, which were reported associated with Alzheimer’s disease in two studies [12,13].