PRF1 and neoplasm: CD8+ or CD4+T‐lymphocytes recognize cancer antigens or over‐expressed self‐antigens processed by DCs through T‐cell receptors (TCRs).72 Upon recognition of tumor antigens by TCR/MHC engagement, activated CD8+ cytotoxic T cells (CTLs) directly kill malignant cells by mechanisms including perforin/granzyme secretion and/or FasL/Fas binding.