IDH1 and central nervous system cancer: For instance, PLK1 was elevated in glioblastoma multiforme cells and its inhibition suppressed cell growth and induced cell death.19 In medulloblastoma, down‐regulation of PLK1 impaired tumour sphere formation of medulloblastoma cells and induced cell apoptosis.13 Additionally, Koncar et al demonstrated that PLK1 inhibition enhanced TMZ efficacy in IDH1 mutant gliomas.14 Additional modalities of TMZ‐resistant such as PLK1 expression further complicate the mechanism of glioma drug resistance.