More recent data also describe a pathogenic role CCR6+ T cells within the exFoxp3+ T cells, which have the potential to express RANKL and IL‐17 upon co‐culture with synovial fibroblasts and therefore enhance osteoclastogenesis.31 In addition, higher proportions of CCR6+ T cells within peripheral blood mononuclear cells were observed in RA patients with anti‐citrullinated antibodies (ACPAs). This evidence concerns the gene TNFSF11 and rheumatoid arthritis.