These last outcomes point that, even when endogenous endothelial VEGFR2 is critical for the growing of abnormal blood vessels, external input from RPE‐derived exosomes might be decisive for the distinctive angiogenesis observed in neovascular eye diseases, such as AMD and DR, and that this exosome release is directly related to autophagy. Here, KDR is linked to age-related macular degeneration.