This effect was observed in RPE cells of aged mice and AMD patients.22 It was also observed that OS in ARPE‐19 cells does not kill them, but rather enhances autophagy,2 VEGF release41 and exosome liberation.19 In this sense, RPE cells have been reported to express p62 in conditions of autophagy impairment in a collagen XVIII‐deficient mouse model.42 The gene discussed is VEGFA; the disease is age-related macular degeneration.