IL‐18 is a member of the IL‐1 family of cytokines.37 Elevated expression of serum IL‐18 is seen in children and murine models.38, 39 It has been shown to be elevated in the SC of adults with AD40, 41 and in the serum of infants and children with AD, correlating with disease activity.42, 43 We also found CXCL8 (IL‐8) to be significantly increased in the SC and correlated with disease severity and barrier dysfunction, further supporting the role of innate activation. This evidence concerns the gene IL1A and Alzheimer disease.