ACVRL1 and glioblastoma: Nonetheless, the tumor types with highest expression of ACVRL1, namely KIRC and GBM, displayed GSEA profiles that were distinct from those of the remaining cohorts included in this investigation; KIRC showed negative enrichment scores for all metabolic processes and protein production, whereas GBM only showed positive enrichment for all the reference hallmarks (Fig. 3a and Supplementary Table 3).