STAT3 and neoplasm: All the tumor types shared a core of processes associated to the tumor microenvironment and its composition (Fig. 3a), including angiogenesis (Fig. 3b), EMT (Fig. 3c) and immune regulation (Fig. 3d); strikingly, all the gene sets related to immune function, i.e., “inflammatory response,” “complement,” “interferon-γ,” “IL2/STAT5” and “IL6/JAK/STAT3” signaling, “TNF-α,” “coagulation,” and “allograft rejection,” showed a coherent association with ACVRL1 expression (Fig. 3a and Supplementary Table 3).