Nonetheless, based on much more similar experimental setups, the reduced sprouting of VEGF-stimulated HUVEC in vitro, as well as the reduced tumor volume and associated vascular density in vivo reported in Clec14a knock-out mice [45], phenocopies the effects of ALK1 inhibition observed in different studies [8, 10, 11]. This evidence concerns the gene CLEC14A and neoplasm.