Nonetheless, the tumor types with highest expression of ACVRL1, namely KIRC and GBM, displayed GSEA profiles that were distinct from those of the remaining cohorts included in this investigation; KIRC showed negative enrichment scores for all metabolic processes and protein production, whereas GBM only showed positive enrichment for all the reference hallmarks (Fig. 3a and Supplementary Table 3). Here, ACVRL1 is linked to neoplasm.