INS and type 1 diabetes mellitus: More recently, two large multicentre RCTs, ADJUNCT ONE (N = 1400) [14] and REMOVAL (REducing with MetfOrmin Vascular Adverse Lesions; N = 428) [15], examined the effectiveness of the glucagon-like peptide-1 receptor agonist liraglutide (1.2 mg and 1.8 mg doses) and metformin, respectively, as adjuncts to insulin therapy in type 1 diabetes.