Although PD most often occurs sporadically, increasing evidence points to underlying genetic predispositions that can alter the incidence and progression of PD.24,26,48,49 PPMI was initiated to expand our understanding of genetic variation occurring in association with PD and is unique in its inclusion of exome sequence data obtained from patients with SWEDD along with data obtained from PD patients and controls.33 We took advantage of the PPMI exome sequence data to evaluate genetic variation in NLRP3. In these studies, we evaluated NLRP3 SNPs with an MAF ≥ 5%. Here, NLRP3 is linked to Parkinson disease.