NLRP3 polymorphisms are associated with multiple human inflammatory disorders, including the cryopyrin-associated periodic syndromes (CAPS) spectra,43 inflammatory bowel disease,44 primary gouty arthritis,45 and psoriatic idiopathic juvenile arthritis.46 Recent reports identify polymorphisms in NLRP3 in patients with late-onset AD in a Han Chinese population where the SNP rs35829419 was associated with a reduced risk of developing AD.47 In this study, AD-associated SNPs with an MAF ≥ 5% were identified only within non-coding regions. The gene discussed is NLRP3; the disease is Alzheimer disease.