In addition to pigmented cell bodies, we analyzed NLRP3 immunoreactivity in Lewy neurites, non-pigmented, α-synuclein immunoreactive neuronal processes observed in PD.31 Staining for α-synuclein, we confirmed the presence of these processes only in histologic sections obtained from PD patients (Fig. 1f, left panel). Here, NLRP3 is linked to Parkinson disease.