We report detection of NLRP3 expression in DA neurons in PD patients, a finding related to a recent report by Zhang et al., who found expression of the canonical inflammasome targets IL-1β and IL-18 in cerebrospinal fluid obtained from PD patients.15 These findings of neuronal inflammasome expression in human tissues extend previous reports that identified neuronal NLRP1,13AIM2,14 and NLRP315 expression and function in rodents.12 Collectively, these studies suggest that, in neurons, inflammasome proteins may be an important component of the cellular stress response. Here, IL18 is linked to Parkinson disease.