Our findings of multiple polymorphisms within the NLRP3 NACHT domain are consistent with NLRP3 mutations associated with CAPS syndromes that also frequently occur in exon 3.51 We identified one synonymous SNP in the NLRP3 NACHT domain, rs7525979, statistically associated with a reduced risk of PD. The gene discussed is NLRP3; the disease is Parkinson disease.