NLRP3 and nervous system disorder: Postmortem analyses clearly indicate that neuroinflammation is associated with PD3 and many of the environmental and genetic risk factors postulated for PD29,30,38 are believed to impact the inflammatory state of the brain.39 Inflammasomes have only recently been identified in the CNS40 and our animal studies suggest that they might be a rational target for anti-inflammatory intervention to treat neurologic disorders associated with inflammation.11 Here we conduct histologic and genetic studies in PD patients to determine whether NLRP3 may play a role in the onset and progression of disease.