NLRP3 and Parkinson disease: We used exome sequence data obtained through the PPMI to identify coding region SNPs (n = 644: 402 PD patients, 60 SWEDD, and 182 controls).33 Twenty-two SNPs in NLRP3 were available in the sequencing data, four SNPs had a minor allele frequency (MAF) ≥ 5% and were selected for further analysis (rs7525979, rs3806268, rs34298354, and rs35829419) (Fig. 2a).