Increased expression of NLRP3 and molecular chaperone proteins, as observed in our study (Fig. 3), may be the result of altered translation efficiency and disrupted protein folding, which in turn may impact protein function in a variety of ways, including deregulated proteosomal degradation, and/or formation of misfolded protein aggregates.59 Our data from the analysis in HEK293 cells enables us to predict that the NLRP3 SNP rs7525979 reduces the risk of PD by altering the NLRP3 protein life cycle. The gene discussed is NLRP3; the disease is Parkinson disease.