They further provide evidence that, in order to establish optimal personalized, immune-related therapies, in breast cancer patients, one should, in addition to the targeting of the stroma and cancer-infiltrating immune cells (8), also investigate and target tumor cells, as was recently reported for another member of the TNFRSF, TNFR2 (10, 11). This evidence concerns the gene TNFRSF1B and cancer.