PIEZO2 and respiratory system disorder: As an example (Table 1, case 7), we identified distinct PIEZO2 variants (p.Glu2727del and p.Ile802Phe) in two separate patients with the musculoskeletal contracture and respiratory disease Distal Arthrogryposis type 5 (DA5).23 One of the patients presented to our emergency department in acute respiratory distress during flu season.