The data-driven, pathway enrichment analysis of this data, as well as additional proteomic datasets from our preclinical and in vitro models of NAFLD, identified the PPARα regulome as a key regulatory network module in liver adaptation to lipid loading.28,29 Due to the large scale of this omics data derived regulatory network, parameterisation of a fully quantitative model was not feasible. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatotic liver disease.