PPARA and metabolic dysfunction-associated steatotic liver disease: The identification of PPARα as a key regulatory network module in liver adaptation to lipid loading was interesting given the potential clinical role for PPARα activation in NAFLD treatment, with dual and selective PPAR modulators currently in phase 2 and phase 3 clinical trials.45 Activation of PPARα induces genes involved in fatty acid binding, transport, and β-oxidation, thereby promoting the uptake, utilisation, and catabolism of fatty acids.