Interestingly, treatment of aortic vascular with adipocyte-derived conditioned medium (CM) pretreated with adenovirus RPS3A significantly decreased the mRNA expression levels of TNFα, IL-1β, IL-6, ICAM1, and VCAM1 (Fig. 7f, g), and demonstrated that overexpression of RPS3A in brown adipocytes inhibited inflammation of vascular, thereby protecting from atherosclerosis. Here, ICAM1 is linked to atherosclerosis.