Among them, the classification criteria of TRG was shown as follows: TRG1, absence of residual cancer and extensive fibrosis; TRG2, rare residual cancer cells scattered through the fibrosis; TRG3, increased residual cancer cells but fibrosis still predominating; TRG4, residual cancer outgrowing fibrosis; TRG5, absence of regressive changes. Here, SAMM50 is linked to cancer.