For example, by comparing the protein component of the whole-cell extracts and conditioned medium of primary cancer-associated fibroblasts (CAF) and normal fibroblasts isolated from mice with azoxymethane and dextrane sodium sulfate induced CRC, Torres and colleagues identified several proteins, including FSTL1, which were deregulated in tumoral samples [16]. The gene discussed is FSTL1; the disease is colorectal carcinoma.