Further, the NF1 gene is frequently mutated in various types of sporadic human cancers, including glioblastoma [18], neuroblastoma [19], acute myeloid leukemia [20], as well as lung [21], ovarian [22] and breast tumors [23], thus highlighting a broader role for NF1 in human cancer. This evidence concerns the gene NF1 and acute myeloid leukemia.