On the basis of exome and genome sequencing studies, cutaneous melanoma is divided into four different molecular subgroups: The first group includes BRAF (most often BRAFV600E) mutant melanomas, the second group are NRASQ61L/R mutant melanomas, the third group are NF1 mutant melanomas, and the fourth group are triple wild-type melanomas [2]. Here, NF1 is linked to melanoma.