APC and colon adenoma: Ten genomic regions of interest were selected for further study (Figure 5) based on differential expression of their encoded transcripts following APC loss in both cell culture (Figure 2B) and mouse colon adenoma (Figure 2C) models, and successful APC ChIP-qPCR validation comparable to positive control peaks clearly visible by qPCR in Supplementary Figure 3B (although the overall purpose of the figure is different).