APC and colon adenoma: To circumvent these limitations and select candidate targets shared with in vivo models of tumorigenesis, genes of interest were filtered further using colon adenoma RNA-seq data from two mouse models of colon tumorigenesis on a C57BL/6J background [15]: one expressing wild-type Apc and a degradation-resistant mutant β-catenin (as a result of treatment with azoxymethane and dextran sulfate sodium (AOM/DSS-treated) [16]) and the other with loss of function mutations of Apc (ApcMin/+) (Figure 1E).