Of note, when quantifying α4β7 expression in LPMCs from seven IBD patients prior to initiation of VDZ therapy, we observed similar expression levels compared with those seen in peripheral blood lymphocytes with highest expression in mucosal CD19+ B cells (32%) and CD3+ (20%), CD4+ (11%), and CD8+ (25%) T cells (Figure S1D in Supplementary Material). Here, CD4 is linked to inflammatory bowel disease.