Furthermore, several members of the matrix metalloproteinase (MMP) family were upregulated such as MMP-1, MMP-3, MMP7, ADAM12, ADAMTS12, and ADAMTS2 consistent with the known role of MMPs for tissue degradation, the persistence of the inflammatory state, and fibrosis associated with IBD (50). The gene discussed is MMP3; the disease is inflammatory bowel disease.