We also showed that vesicles from infected cells can carry mRNAs of interferon stimulated genes and further confirmed that vesicles from IFN-treated cells can have a protective effect against the infection, successfully blocking the infection in some of the neighboring cells, which suggests that signals involved in the IFN-mediated response can be carried through EVs and be protective during DENV infection, as immune cells communicate through the EV pathway. Here, IFNA1 is linked to infection.