Therefore, resistin may play a more important role in inflammatory processes rather than in processes involved in adiposity and glucose homeostasis (52).The positive association of DNAJC27 with leptin and resistin supports possible pro-inflammatory roles of this protein in obesity and T2D, in contrast with those of other proteins in the same family, such as DNAJB3. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.