There was a statistically significant interaction between the effects of obesity and diabetes on FBG (P = 0.010); HBA1C (P < 0.001); PAI-1 (P = 0.013).A two-way ANOVA was conducted that examined the effect of obesity and diabetes on DNAJC27. Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.