Therefore, resistin may play a more important role in inflammatory processes rather than in processes involved in adiposity and glucose homeostasis (52).The positive association of DNAJC27 with leptin and resistin supports possible pro-inflammatory roles of this protein in obesity and T2D, in contrast with those of other proteins in the same family, such as DNAJB3. This evidence concerns the gene DNAJB3 and obesity due to melanocortin 4 receptor deficiency.