SIRT1 and cardiac hypertrophy: SIRT1 upregulation is associated with cardioprotection since heart-specific SIRT1 overexpression protects the heart against cardiac dysfunction and cell death (Alcendor et al., 2007), cardiac hypertrophy (Planavila et al., 2011), and mediates the cardioprotective effects of ischemic preconditioning (Nadtochiy et al., 2011).