SIRT3 and cardiac hypertrophy: Also, cardiac-specific SIRT3 overexpression prevented angiotensin II- and doxorubicin-induced cardiac hypertrophy, fibrosis, and fetal gene expression (Sundaresan et al., 2009; Pillai et al., 2016) confirming that SIRT3 has a role in protecting the heart against hypertrophic stimuli.