Several groups have reported that SIRT3 physically interacted with the OSCP subunit in human osteosarcoma cells (Wu et al., 2013), HEK293T cells (Wu et al., 2013; Yang et al., 2016a), and HCT116 cells (Vassilopoulos et al., 2014). This evidence concerns the gene SIRT3 and osteosarcoma.