IGFBP1 and obesity due to melanocortin 4 receptor deficiency: Our list of DEGs overlapped significantly with that reported recently (Altmae et al., 2017), including suppression of genes that play a role in immunity (IL1R2, IL2RB, TNFSF10, and FN1) and pregnancy complications associated with pregravid obesity (e.g., intrauterine growth restriction, placental insufficiency, large for gestational age, miscarriage, and preeclampsia) (IGFBP1, IGFBP2, PRL, TAC3, RBP4, DKK1, TIMP3, FSTL3, and IGFBP1) (Okamoto et al., 2006; Zhang et al., 2013; Sober et al., 2015).