CD22 and immune system disorder: DEGs that enriched to “immune system diseases” played critical roles in cell-matrix communication (THY1, LVRN, LUM, TIMP3, SPOCK1, LGALS3BP, FAT2, and SERPINE2) as well as inflammation (IL1R2, CD22, PTGES, TNFSF10, IL2RB, C3, SERPING1, and IL-17RE) (Figure 4E).