CAMK2G and cardiac hypertrophy: Thus, sustained, excessive CaMKII activation is considered to be an upstream signaling event for increased LTCC opening probability, which is involved in excitation-contraction coupling dysfunction, myocardial hypertrophy, heart failure, and lethal arrhythmia (Wu et al., 1999; Rokita and Anderson, 2012; Zhu et al., 2016).