CYP51A1 and type 2 diabetes mellitus: In addition, a study by Ren et al. (2016) found that CYP51A1 (lanosterol 14-α-demethylase) is involved in the metabolism of sulfonylureas in type II diabetes and can cause changes in the amount of glycosylated hemoglobin (HbA1c); Ding et al. (2015) found that CYP51A1 is involved in cholesterol metabolism.