BDNF and Hyperinsulinemia: In mice, global BDNF haploinsufficiency or brain-specific BDNF depletion results in excessive feeding and body weight gain accompanied by other features of the associated metabolic syndrome, including hyperleptinemia, hyperglycemia, and hyperinsulinemia (Rios et al., 2001; Beckers et al., 2008; Skledar et al., 2012).