CFTR and cystic fibrosis: These experiments demonstrate that these anionophores could be used to promote chloride and bicarbonate transport in cells, i.e., are good candidates to replace the defective or missing CFTR in an attempt to design a new cystic fibrosis therapy, as proposed for other anion transporters (Shen et al., 2012; Valkenier et al., 2014; Li et al., 2016, 2017; Liu et al., 2016; Dias et al., 2018).