By mediating nucleotide transport, ABCC4 influences various purinergic signaling pathways, which depending on the local conditions, either inhibits or stimulates cell survival, proliferation, invasion and metastasis in various types of cancer (Choi et al., 2003) and may lead to an altered expression of HER-2 (Chen et al., 2016). This evidence concerns the gene ERBB2 and cancer.