It was indicated that the N-M tumor metastasis pattern and a putative ovarian origin, rather than tubular origin, are associated with a more favorable prognosis (Auer et al., 2017), which would be in line with a role of SLCO2A1 and HPGD implicated in the degradation of pro-inflammatory prostaglandins. This evidence concerns the gene HPGD and neoplasm.