Notably, the chosen enzymes PTGS2 and PGDH were used because of the importance of PTGS2 and PGDH in regulating PGE2 levels and their potential influence on inflammatory processes in cancer (Nomura et al., 2004), whereas SULT1E1 was used because it was shown that higher SULT1E1 protein levels were associated with an improved OS rate in HGSOC (Mungenast et al., 2017). Here, HPGD is linked to cancer.