NOTCH1 and Stroke: Notably, preventing Notch1 cleavage into the Notch intracellular domain (NICD) with the γ-secretase inhibitor N-[N-(3,5-diuorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester (DAPT), subsequently improves functional outcomes following stroke (Li et al., 2012).