AKT1 and brain neoplasm: Interestingly, dysregulation of the FMRP/Akt/mTOR pathway has been reported to promote tumorigenesis (Rajasekhar et al., 2003; Lucá et al., 2013) and impaired mTOR cascade has especially been linked to Glioblastoma, the most common form of primary brain tumor (Akhavan et al., 2010; Li et al., 2016).