Caspase-3 is a target gene of HIF-1α (Van Hoecke et al., 2007; Chen et al., 2009); HIF-1 functionally binds to the caspase-3 promoter after photothrombotic cerebral ischemia (Van Hoecke et al., 2007). The gene discussed is CASP3; the disease is Cerebral ischemia.