TARDBP and amyotrophic lateral sclerosis: As documented also by a recent study, an overload of Na+ and Ca2+ ions induced by veratridine combined with TDP-43 overexpression increases early apoptosis of NSC-34 cells and may represent a valid in vitro model of ALS involvement of sodium homeostasis-deregulation in ALS (Mouhid Al-Achbili et al., 2016).