Hereupon, we documented the importance of the plasmamembrane Na+/Ca2+ exchanger isoform 3 (NCX3) in ALS pathogenesis because animals affected by ALS show a strong reduction in its expression and activity at muscular and neuronal levels, whereas strategies able to delay ALS progression worked also through NCX3 activation and overexpression (Anzilotti et al., 2018). This evidence concerns the gene SLC8A3 and amyotrophic lateral sclerosis.