Moreover Na+ conductance increase has also been reported in transgenic SOD1 mice although mechanisms of ectopic activity, such as cramp and fasciculations, and axonal degeneration still necessitate clarifications in patients affected of familiar ALS (fALS), and, specifically, it is not clear whether any difference occurs with the processes identified in subjects affected by the sporadic form of ALS (sALS). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.