Stimulation of PPAR-α by PEA or synthetic PPAR-α agonists was recently shown to elevate corticolimbic allopregnanolone levels in hippocampus, amygdala, frontal cortex and in olfactory bulb, which correlated with improvement of PTSD-like behavior in socially isolated mice (Locci and Pinna, 2017a). This evidence concerns the gene PPARA and post-traumatic stress disorder.